Plinabulin - CISMeF

Preferred Label : Plinabulin;

NCIt synonyms : (3Z,6Z)-6-benzylidene-3-{[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylidene}piperazine-2,5-dione;

NCIt definition : An orally active diketopiperazine derivative with potential antineoplastic activity. Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, thereby interrupting equilibrium of microtubule dynamics. This disrupts mitotic spindle assembly leading to cell cycle arrest at M phase and blockage of cell division. In addition, plinabulin may also inhibit growth of proliferating vascular endothelial cells, thereby disrupting the function of tumor vasculature that further contributes to a decrease in tumor cell proliferation.;

UNII : 986FY7F8XR;

InChIKey : UNRCMCRRFYFGFX-TYPNBTCFSA-N;

CAS number : 714272-27-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 714272-27-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : NPI-2358;

Chemical formula : C19H20N4O2;

Codes from synonyms : 409;

Details

Origin ID

C62444;

UMLS CUI

C2987723;

Automatic exact mappings (from CISMeF team)
- NPI 2358 [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- plinabulin [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- plinabulin [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Mitosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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