Amphotericin B Deoxycholate

Preferred Label : Amphotericin B Deoxycholate;

NCIt synonyms : Amphotericin B-deoxycholate;

NCIt related terms : Fungizone;

NCIt definition : The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane. This results in depolarization of the cell membrane, alterations in cell membrane permeability, leakage of important intracellular components, and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.;

CAS number : 58501-21-6;

Drug name : Fungizone;

Codes from synonyms : NSC0527017;

Details

Origin ID

C62201;

UMLS CUI

C0051761;

Currated CISMeF NLP mapping
- AMPHOTERICIN B DEOXYCHOLATE [SMS substance]
- amphotericin B, deoxycholate drug combination [MeSH concept]
- amphotericin B, deoxycholate drug combination [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- amphotericin B, deoxycholate drug combination [MeSH concept]
- amphotericin B, deoxycholate drug combination [MeSH Supplementary Concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Amphotericin B [NCIt concept]
is_salt_form_of
- Amphotericin B [NCIt concept]

Keyword's position in hierarchy(ies) :

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