Amphotericin B

Preferred Label : Amphotericin B;

NCIt synonyms : AmB; Amphotercin B;

NCIt definition : A polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.;

Alternative definition : NCI-GLOSS: A drug used in the treatment of infections caused by fungi. It is a type of antifungal.;

UNII : 7XU7A7DROE;

InChIKey : APKFDSVGJQXUKY-INPOYWNPSA-N;

CAS number : 1397-89-3;

Drug name : Amphotec; Amphocil;

Chemical formula : C47H73NO17;

NSC code : 527017;

ChEBI ID : CHEBI:2682;

Codes from synonyms : 30128; NSC0527017; CDR0000045173;

Details

Origin ID

C238;

UMLS CUI

C0002679;

See also inter- (CISMeF)
- Product containing amphotericin B (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Amphotericin B [ICD-11 Extension code]
- Amphotericin B [LOINC component]
- Amphotericin B (substance) [SNOMED CT concept]
- Product containing amphotericin B (medicinal product) [SNOMED CT concept]
- amphotericin B [MeSH concept]
- amphotericin B [MeSH Descriptor]
- amphotericin b [ATC Code]
- amphotericin b [ATC Code]
- amphotericin b [ATC Code]
- amphotericin b [ATC Code]
- amphotericin b [Substance BNPC]
- amphotericin b [SNOMED Notion]
Validated automatic mappings to BTNT
- amphotericin b [ATC Code]
- amphotericin b [ATC Code]
- amphotericin b [ATC Code]
- amphotericin b [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Amphotericin B Deoxycholate [NCIt concept]
is_component_of_chemotherapy_regimen
- Amphotericin B/Colistin Sulfate/Tobramycin [NCIt concept]
- Amphotericin B/Flucytosine [NCIt concept]
is_free_acid_or_base_form_of
- Amphotericin B Deoxycholate [NCIt concept]

Keyword's position in hierarchy(ies) :

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