Thiethylperazine

Preferred Label : Thiethylperazine;

NCIt synonyms : Thiethylperazine Base;

NCIt definition : A piperazine phenothiazine derivative and a dopamine antagonist used as antiemetic. Thiethylperazine blocks postsynaptic dopamine 2 (D2) receptors in the medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain. Peripherally, thiethylperazine blocks the vagus nerve in the gastrointestinal tract. In addition, this agent also shows antagonistic activities mediated through muscarinic receptors, H1-receptors, and alpha(1)-receptors.;

Alternative definition : NCI-GLOSS: A drug used to prevent or reduce nausea and vomiting. It belongs to the families of drugs called antiemetics and phenothiazines.;

UNII : 8ETK1WAF6R;

InChIKey : XCTYLCDETUVOIP-UHFFFAOYSA-N;

CAS number : 1420-55-9;

Chemical formula : C22H29N3S2;

ChEBI ID : CHEBI:9544;

Codes from synonyms : CDR0000467870;

Details

Origin ID

C62081;

UMLS CUI

C0039865;

Currated CISMeF NLP mapping
- Thiethylperazine [LOINC component]
- Thiethylperazine [ICD-11 Extension code]
- Thiethylperazine (substance) [SNOMED CT concept]
- thiethylperazine [Substance BNPC]
- thiethylperazine [MeSH Descriptor]
- thiethylperazine [MeSH concept]
- thiethylperazine [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing thiethylperazine (medicinal product) [SNOMED CT concept]
- Thiethylperazine [LOINC component]
- Thiethylperazine [ICD-11 Extension code]
- Thiethylperazine (substance) [SNOMED CT concept]
- thiethylperazine [ATC Code]
- thiethylperazine [Substance BNPC]
- thiethylperazine [MeSH concept]
- thiethylperazine [MeSH Descriptor]
- thiethylperazine [SNOMED Notion]
Validated automatic mappings to BTNT
- thiethylperazine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Thiethylperazine Maleate [NCIt concept]
is_free_acid_or_base_form_of
- Thiethylperazine Maleate [NCIt concept]

Keyword's position in hierarchy(ies) :

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