" /> Thiethylperazine - CISMeF





Preferred Label : Thiethylperazine;

NCIt synonyms : Thiethylperazine Base;

NCIt definition : A piperazine phenothiazine derivative and a dopamine antagonist used as antiemetic. Thiethylperazine blocks postsynaptic dopamine 2 (D2) receptors in the medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain. Peripherally, thiethylperazine blocks the vagus nerve in the gastrointestinal tract. In addition, this agent also shows antagonistic activities mediated through muscarinic receptors, H1-receptors, and alpha(1)-receptors.;

Alternative definition : NCI-GLOSS: A drug used to prevent or reduce nausea and vomiting. It belongs to the families of drugs called antiemetics and phenothiazines.;

UNII : 8ETK1WAF6R;

InChIKey : XCTYLCDETUVOIP-UHFFFAOYSA-N;

CAS number : 1420-55-9;

Chemical formula : C22H29N3S2;

ChEBI ID : CHEBI:9544;

Codes from synonyms : CDR0000467870;

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08/05/2025


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