Thiethylperazine Maleate

Preferred Label : Thiethylperazine Maleate;

NCIt synonyms : 10H-Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-2-butenedioate; Thiethylperazine;

NCIt definition : The maleate salt form of triethylperazine, a piperazine phenothiazine derivative and a dopamine antagonist used as antiemetic. Thiethylperazine blocks postsynaptic dopamine 2 (D2) receptors in the medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain. Peripherally, thiethylperazine blocks the vagus nerve in the gastrointestinal tract. In addition, this agent also shows antagonistic activities mediated through muscarinic receptors, H1-receptors, and alpha(1)-receptors.;

UNII : RUK64CF26E;

InChIKey : RVBRTNPNFYFDMZ-SPIKMXEPSA-N;

CAS number : 1179-69-7;

Drug name : Torecan; Norzine;

Molecule name : GS-95;

Chemical formula : C22H29N3S2.2C4H4O4;

NSC code : 130044;

ChEBI ID : CHEBI:32216;

Détails

Origin ID

C29497;

UMLS CUI

C0242518;

Automatic exact mappings (from CISMeF team)
- Product containing thiethylperazine (medicinal product) [SNOMED CT concept]
- Thiethylperazine [LOINC component]
- Thiethylperazine [ICHI extension code]
- Thiethylperazine (substance) [SNOMED CT concept]
- thiethylperazine [MeSH Descriptor]
- thiethylperazine [ATC Code]
- thiethylperazine [Substance BNPC]
- thiethylperazine [SNOMED Notion]
- thiethylperazine [MeSH concept]
Currated CISMeF NLP mapping
- Thiethylperazine Maleate (2:1) [MeSH concept]
- Thiethylperazine malate (substance) [SNOMED CT concept]
- Thiethylperazine maleate (substance) [SNOMED CT concept]
- thiethylperazine di(hydrogen maleate) [Substance BNPC]
- thiethylperazine malate [SNOMED Notion]
- thiethylperazine malate [MeSH concept]
- thiethylperazine maleate [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Thiethylperazine malate (substance) [SNOMED CT concept]
- Thiethylperazine maleate (substance) [SNOMED CT concept]
- thiethylperazine di(hydrogen maleate) [Substance BNPC]
- thiethylperazine malate [MeSH concept]
- thiethylperazine malate [SNOMED Notion]
- thiethylperazine maleate [SNOMED Notion]
Validated automatic mappings to NTBT
- Thiethylperazine [ICD-11 Extension code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Thiethylperazine [NCIt concept]
is_salt_form_of
- Thiethylperazine [NCIt concept]

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