Preferred Label : Hydromorphone;
NCIt synonyms : Hydromorphon; Dihydromorphinone; Hydromorphone Base;
NCIt related terms : (-)-Hydromorphone;
NCIt definition : The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects.
Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins.
Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate
(GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located
at the inner surface of the plasma membrane. This leads to a reduction in intracellular
cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels
are activated, thereby causing hyperpolarization and reducing neuronal excitability.
In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading
to an inhibition of calcium entry and a reduction in the release of various neurotransmitters,
including GABA, vasopressin, somatostatin, insulin and glucagons.;
Alternative definition : NCI-GLOSS: A drug used to relieve pain.;
UNII : Q812464R06;
InChIKey : WVLOADHCBXTIJK-YNHQPCIGSA-N;
CAS number : 466-99-9;
Chemical formula : C17H19NO3;
ChEBI ID : CHEBI:5790;
Codes from synonyms : CDR0000045217; NSC0019046;
Origin ID : C62034;
UMLS CUI : C0012306;
Currated CISMeF NLP mapping
- False automatic mappings
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
