Preferred Label : Hydromorphone Hydrochloride;
NCIt related terms : Dilaudid; Hydromorphone; Laudicon;
NCIt definition : The hydrochloride salt form of hydromorphone, the hydrogenated ketone of morphine,
a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the
mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange
of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex
and interacts with and inhibits adenylate cyclase located at the inner surface of
the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine
monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby
causing hyperpolarization and reducing neuronal excitability. In addition, the opening
of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of
calcium entry and a reduction in the release of various neurotransmitters, including
GABA, vasopressin, somatostatin, insulin and glucagons.;
UNII : L960UP2KRW;
InChIKey : XHILEZUETWRSHC-NRGUFEMZSA-N;
CAS number : 71-68-1;
Drug name : Exalgo; Dilaudid; Hydrostat; Laudicon; Dilaudid HP; Hymorphan; Novolauden; Dimorphone;
Chemical formula : C17H19NO3.HCl;
NSC code : 19046;
ChEBI ID : CHEBI:5791;
Codes from synonyms : NSC0117862; NSC0019046;
Origin ID : C436;
UMLS CUI : C0700533;
Automatic exact mappings (from CISMeF team)
See also inter- (CISMeF)
Semantic type(s)
Validated automatic mappings to NTBT
concept_is_in_subset
has_free_acid_or_base_form
is_salt_form_of