" /> Hydromorphone Hydrochloride - CISMeF





Preferred Label : Hydromorphone Hydrochloride;

NCIt related terms : Dilaudid; Hydromorphone; Laudicon;

NCIt definition : The hydrochloride salt form of hydromorphone, the hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.;

UNII : L960UP2KRW;

InChIKey : XHILEZUETWRSHC-NRGUFEMZSA-N;

CAS number : 71-68-1;

Drug name : Exalgo; Dilaudid; Hydrostat; Laudicon; Dilaudid HP; Hymorphan; Novolauden; Dimorphone;

Chemical formula : C17H19NO3.HCl;

NSC code : 19046;

ChEBI ID : CHEBI:5791;

Codes from synonyms : NSC0117862; NSC0019046;

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07/05/2025


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