NCIt definition : An amide-type, long-acting local anesthetic. Bupivicaine reversibly binds to specific
sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent
membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization
and nerve impulse conduction; and a reversible loss of sensation.;
Alternative definition : NCI-GLOSS: A drug used to relieve pain by blocking signals at nerve endings. It is
being studied in the relief of pain following surgery for cancer. It is a type of
local anesthetic.;