NCIt definition : The sodium salt form of tolmetin, an arylalkanoic acid and non-steroidal anti-inflammatory
drug (NSAID) with analgesic, anti-inflammatory and antipyretic activities. Although
the exact mechanism through which tolmetin exerts its effects has yet to be fully
elucidated, this agent appears to inhibit the enzyme prostaglandin synthase. This
prevents the formation of prostaglandins from prostaglandin precursors, including
the synthesis of the inflammatory prostaglandin E2 (PGE2) from the precursor prostaglandin
H2 (PGH2). This prevents prostaglandin-mediated effects, including pain, inflammation
and fever.;