NCIt definition : An arylalkanoic acid and non-steroidal anti-inflammatory drug (NSAID) with analgesic,
anti-inflammatory and antipyretic activities. Although the exact mechanism through
which tolmetin exerts its effects has yet to be fully elucidated, this agent appears
to inhibit the enzyme prostaglandin synthase. This prevents the formation of prostaglandins
from prostaglandin precursors, including the synthesis of the inflammatory prostaglandin
E2 (PGE2) from the precursor prostaglandin H2 (PGH2). This prevents prostaglandin-mediated
effects, including pain, inflammation and fever.;