Preferred Label : Propoxyphene;
NCIt synonyms : d-Propoxyphene; Dextropropoxyphene; 4-Dimethylamino-3-methyl-1,2-diphenyl-2-propoxybutane;
NCIt definition : The d-isomer of synthetic diphenyl propionate derivative propoxyphene, with narcotic
analgesic effect. This agent mimics the effects of the endogenous opiate dextropropoxyphene,
by binding to mu receptors located throughout the central nervous system. The binding
results in GTP to GDP exchanges on the mu-G-protein complex, by which effector adenylate
cyclase is inactivated thereby decreasing intracellular cAMP. This, in turn, inhibits
the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric
acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin.
In addition, dextropropoxyphene closes N-type voltage-gated calcium channels and opens
calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization,
thereby reducing neuronal excitability, which further decreases the perception of
pain.;
UNII : S2F83W92TK;
InChIKey : XLMALTXPSGQGBX-GCJKJVERSA-N;
CAS number : 469-62-5;
Drug name : Proxagesic; Femadol; Antalvic; Proxyvon; Algafan;
Molecule name : SK 65;
Chemical formula : C22H29NO2;
ChEBI ID : CHEBI:51173;
Origin ID : C61912;
UMLS CUI : C0033493;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
