Preferred Label : Propoxyphene Hydrochloride;
NCIt synonyms : Dextropropoxyphene Hydrochloride; Doloxene; Doraphen; d-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol Propionate Hydrochloride; alpha-d-Propoxyphene Hydrochloride;
NCIt definition : The hydrochloride salt form of the d-isomer of synthetic diphenyl propionate derivative
propoxyphene, with narcotic analgesic effect. This agent mimics the effects of the
endogenous opiate dextropropoxyphene, by binding to mu receptors located throughout
the central nervous system. The binding results in GTP to GDP exchanges on the mu-G-protein
complex, by which effector adenylate cyclase is inactivated thereby decreasing intracellular
cAMP. This, in turn, inhibits the release of various nociceptive neurotransmitters,
such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline,
vasopressin, and somatostatin. In addition, dextropropoxyphene closes N-type voltage-gated
calcium channels and opens calcium-dependent inwardly rectifying potassium channels.
This results in hyperpolarization, thereby reducing neuronal excitability, which further
decreases the perception of pain.;
UNII : CB2TL9PS0T;
InChIKey : QMQBBUPJKANITL-MYXGOWFTSA-N;
CAS number : 1639-60-7;
Drug name : Zideron; Dolene; Dolotard;
Molecule name : SK 65;
Chemical formula : C22H29NO2.HCl;
NCI Metathesaurus CUI : CL449034;
ChEBI ID : CHEBI:8498;
Origin ID : C29385;
UMLS CUI : C0242451;
Currated CISMeF NLP mapping
- False automatic mappings
- Semantic type(s)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
