Pramocaine - CISMeF

Preferred Label : Pramocaine;

NCIt synonyms : Pramoxine; 4-(3-(p-Butoxyphenoxy)propyl)morpholine;

NCIt definition : A morpholine derivative with local anesthetic property. Pramocaine decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and, thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade.;

UNII : 068X84E056;

InChIKey : DQKXQSGTHWVTAD-UHFFFAOYSA-N;

CAS number : 140-65-8;

Chemical formula : C17H27NO3;

ChEBI ID : CHEBI:8357;

Details

Origin ID

C61903;

UMLS CUI

C0071810;

Automatic exact mappings (from CISMeF team)
- Pramoxine [ICHI extension code]
Currated CISMeF NLP mapping
- Pramocaine [SMS substance]
- Pramocaine (substance) [SNOMED CT concept]
- Pramoxine [ICD-11 Extension code]
- pramoxine [Substance BNPC]
- pramoxine [MeSH concept]
- pramoxine [MeSH Supplementary Concept]
- pramoxine [SNOMED Notion]
See also inter- (CISMeF)
- Product containing pramocaine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pramocaine (substance) [SNOMED CT concept]
- Pramoxine [ICD-11 Extension code]
- Product containing pramocaine (medicinal product) [SNOMED CT concept]
- pramocaine [ATC Code]
- pramocaine [ATC Code]
- pramoxine [Substance BNPC]
- pramoxine [MeSH concept]
- pramoxine [SNOMED Notion]
- pramoxine [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- pramocaine [ATC Code]
- pramocaine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Pramocaine Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Pramocaine Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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