Pramlintide Acetate

Preferred Label : Pramlintide Acetate;

NCIt definition : The acetate salt form of pramlintide, a peptide analogue of human amylin with 3 proline substitutions at position 25, 28 and 29, with antihyperglycemic activity. By mimicking amylin, pramlintide slows gastric emptying, inhibits digestive secretions (gastric acid, pancreatic enzymes, and bile), reduces glucagon secretion, and increases satiety; all of these actions are mediated mostly by glucose-sensitive areas in the brain stem. The overall result is a decrease in blood glucose levels. The use of pramlintide may cause an increased risk of insulin-induced hypoglycemia.;

UNII : 726I6TE06G;

CAS number : 196078-30-5;

Drug name : Symlin;

Chemical formula : C171H267N51O53S2.C2H4O2.H2O;

Details

Origin ID

C61902;

UMLS CUI

C1174779;

Currated CISMeF NLP mapping
- Pramlintide acetate (substance) [SNOMED CT concept]
- pramlintide acetate [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pramlintide acetate (substance) [SNOMED CT concept]
- pramlintide acetate [MeSH concept]
Validated automatic mappings to NTBT
- pramlintide [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Pramlintide [NCIt concept]
is_salt_form_of
- Pramlintide [NCIt concept]

Keyword's position in hierarchy(ies) :

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