Polymyxin B1 Sulfate

Preferred Label : Polymyxin B1 Sulfate;

NCIt definition : The sulfate salt form of polymyxin B1, a polypeptide obtained from Bacillus polymyxa strains with antimicrobial activity. Polymyxin B1 exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B1 dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death.;

UNII : 57VAB21ZLF;

InChIKey : HFMDLUQUEXNBOP-GYMBPXIDSA-N;

CAS number : 108965-61-3;

Chemical formula : C56H98N16O13.H2SO4;

Détails

Origin ID

C61897;

UMLS CUI

C1882418;

Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
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- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
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- Polymyxin B1 [NCIt concept]
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- Polymyxin B1 [NCIt concept]

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