" /> Polymyxin B1 - CISMeF





Preferred Label : Polymyxin B1;

NCIt definition : A polypeptide obtained from Bacillus polymyxa strains with antimicrobial activity. Polymyxin B1 exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B1 dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death.;

UNII : B35S89JSRU;

InChIKey : WQVJHHACXVLGBL-CTMZAJDNSA-N;

CAS number : 4135-11-9;

Chemical formula : C56H98N16O13;

ChEBI ID : CHEBI:8309;

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28/05/2025


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