Hydrocortisone Hemisuccinate

Preferred Label : Hydrocortisone Hemisuccinate;

NCIt definition : The synthetic hemisuccinate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes.;

UNII : LIU00Z1Z84;

InChIKey : AFLWPAGYTPJSEY-CODXZCKSSA-N;

CAS number : 83784-20-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 83784-20-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C25H34O8.H2O;

Details

Origin ID

C61786;

UMLS CUI

C0056387;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- hydrocortisone 21-(hydrogen succinate) [Substance BNPC]
- hydrocortisone hemisuccinate [MeSH concept]
- hydrocortisone hemisuccinate [MeSH Supplementary Concept]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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