Hydrocortisone Acetate

Preferred Label : Hydrocortisone Acetate;

NCIt definition : The synthetic acetate ester form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes.;

UNII : 3X7931PO74;

InChIKey : ALEXXDVDDISNDU-JZYPGELDSA-N;

CAS number : 50-03-3;

Chemical formula : C23H32O6;

ChEBI ID : CHEBI:17609;

Details

Origin ID

C61785;

UMLS CUI

C0063077;

Automatic exact mappings (from CISMeF team)
- Hydrocortisone acetate (product) [Inactive SNOMED CT concept]
- Hydroxyamfetamine (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Hydrocortisone acetate (product) [Inactive SNOMED CT concept]
- Hydrocortisone acetate (substance) [SNOMED CT concept]
- hydrocortisone acetate [SNOMED Notion]
- hydrocortisone acetate [MeSH concept]
- hydrocortisone acetate [MeSH Supplementary Concept]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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