NCIt definition : A centrally acting adrenergic agonist with non-stimulant and antihypertensive property.
Guanfacine selectively stimulates alpha-2 adrenergic receptors in the central nervous
system, thereby resulting in inhibition of sympathetic nervous system outflow. Used
alone or in combination with other drugs, this agent causes reduction of peripheral
and renal vascular resistance, and lowers both systolic and diastolic blood pressure
and heart rate.;