NCIt definition : A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial
cells by diffusion through integral membrane porin pathway before targeting both DNA
gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair.
This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the
enzyme thereby preventing the bacterial chromosome from rejoining. This interferes
with DNA replication and repair processes as well as transcription, and ultimately
leads to bacterial cell death. Gemifloxacin targets at both Gram-positive, -negative
and atypical human pathogens.;