NCIt definition : The mesylate salt form of gemifloxacin, a synthetic broad-spectrum fluoroquinolone
with antibacterial activity. Gemifloxacin mesylate inhibits activities of DNA gyrase
and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial
growth. This fluoroquinolone exerts an enhanced spectrum of activity against gram-positive
bacteria such as Streptococcus pneumoniae and Staphylococcus aureus, in addition to
its activity against gram-negative bacteria.;