Preferred Label : 4-Hydroxybutanoic Acid;
NCIt synonyms : Gamma-Hydroxybutyric Acid; 4-Hydroxybutyric Acid; Anetamin; gamma-Hydroxybutyrate; GHB;
NCIt related terms : OXYBATE;
NCIt definition : A naturally occurring short-chain fatty acid, and immediate precursor of gamma amino
butyric acid (GABA) with neuromodulatory and anesthetic properties. 4-Hydroxybutyric
Acid (GHB) is found in all human tissues, with the highest concentration in the brain.
This agent stimulates the GHB receptor, and to a lesser extent GABA-B receptors. Although,
the precise function and metabolic pathways of GHB are not fully understood, this
agent easily crosses the blood-brain barrier, and affects the activities and levels
of dopamine, acetylcholine, dynorphin and serotonin. The primary effect of GHB is
central nervous system depression, thereby, its main usage is to induce anesthesia.;
UNII : 30IW36W5B2;
InChIKey : SJZRECIVHVDYJC-UHFFFAOYSA-N;
CAS number : 591-81-1;
Chemical formula : C4H8O3;
ChEBI ID : CHEBI:30830;
Origin ID : C61773;
UMLS CUI : C0673093;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
