Preferred Label : Fexofenadine;
NCIt definition : A second generation, long-lasting selective histamine H1 receptor antagonist with
antiinflammatory property. Fexofenadine is a highly selective and reversible competitor
at peripheral H1 histamine receptors in the gastrointestinal (GI) tract, blood vessels,
and bronchial smooth muscle. This agent interferes with mediators release from mast
cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane
or by inhibiting intracellular calcium ion release within the cells. In addition fexofenadine
may also inhibit the late-phase allergic reaction by acting on leukotrienes or prostaglandins,
or by producing an anti-platelet activating factor effect. Overall, this agent blocks
the actions of endogenous histamine, thereby leads to temporary relief of the negative
symptoms associated with histamine and achieve effects such as decreased vascular
permeability, reduction of pruritus and localized smooth muscle relaxation.;
Alternative definition : NCI-GLOSS: A drug used to treat certain allergy symptoms. It blocks a chemical released
during an allergic response that causes itching, sneezing, runny nose, wheezing, and
watery eyes. It is a type of antihistamine.;
UNII : E6582LOH6V;
InChIKey : RWTNPBWLLIMQHL-UHFFFAOYSA-N;
CAS number : 83799-24-0;
Chemical formula : C32H39NO4;
ChEBI ID : CHEBI:5050;
Codes from synonyms : CDR0000560967;
Origin ID : C61764;
UMLS CUI : C0296800;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
