Preferred Label : Fexofenadine Hydrochloride;
NCIt synonyms : Fexofenadine HCl; Benzeneacetic Acid, 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethyl-,
Hydrochloride;
NCIt related terms : Allegra;
NCIt definition : The hydrochloride salt form of fexofenadine, a carboxylated metabolic derivative of
terfenadine and second generation, long-lasting selective histamine H1 receptor antagonist,
with antihistaminic activity. Upon administration, fexofenadine competitively binds
of peripheral H1-receptors in the gastrointestinal (GI) tract, blood vessels, and
bronchial smooth muscle. This prevents binding of histamine to peripheral H1-receptors
and prevents their activation. This prevents a histamine-mediated allergic reaction.
Fexofenadine does not cross the blood-brain-barrier (BBB).;
Alternative definition : NCI-GLOSS: A drug used to treat certain allergy symptoms. It blocks a chemical released
during an allergic response that causes itching, sneezing, runny nose, wheezing, and
watery eyes. It is a type of antihistamine.;
UNII : 2S068B75ZU;
InChIKey : RRJFVPUCXDGFJB-UHFFFAOYSA-N;
CAS number : 153439-40-8;
Drug name : Allegra;
Chemical formula : C32H39NO4.HCl;
Codes from synonyms : CDR0000589405;
Origin ID : C29050;
UMLS CUI : C0771752;
Currated CISMeF NLP mapping
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
