Ergotamine - CISMeF

Preferred Label : Ergotamine;

NCIt definition : A naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates serotonin (5-HT) 1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, thereby resulting in vasoconstriction and reducing the blood flow in cerebral arteries that may lead to relieve of vascular headaches. This agent also selectively binds to alpha-adrenergic receptors, thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins, which also contributes to the relief of headaches. Furthermore, the activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.;

UNII : PR834Q503T;

InChIKey : XCGSFFUVFURLIX-VFGNJEKYSA-N;

CAS number : 113-15-5;

Chemical formula : C33H35N5O5;

ChEBI ID : CHEBI:64318;

Details

Origin ID

C61751;

UMLS CUI

C0014710;

Automatic exact mappings (from CISMeF team)
- ergotamines [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ergotamine [ICD-11 Extension code]
- Ergotamine [LOINC component]
- Ergotamine (substance) [SNOMED CT concept]
- Product containing ergotamine (medicinal product) [SNOMED CT concept]
- ergotamine [ATC Code]
- ergotamine [Substance BNPC]
- ergotamine [MeSH concept]
- ergotamine [SNOMED Notion]
- ergotamine [MeSH Descriptor]
Validated automatic mappings to BTNT
- ergotamine [ATC Code]
Validated automatic mappings to NTBT
- ergotamines [MeSH Descriptor]
- ergotamines [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Ergotamine Tartrate [NCIt concept]
is_free_acid_or_base_form_of
- Ergotamine Tartrate [NCIt concept]

Keyword's position in hierarchy(ies) :

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