NCIt definition : The tartrate salt form of ergotamine, an ergot alkaloid and adrenergic alpha agonist
with vasoconstrictor activity. Ergotamine tartrate selectively binds to alpha-adrenergic
receptors thereby stimulating vascular smooth muscle and causing vasoconstriction
in both arteries and veins. Ergotamine tartrate also blocks serotonin 5-HT1D receptors,
thereby also causing vasoconstriction in cerebral blood vessels. Constriction of cerebral
blood vessels caused by this agent may reduce the blood flow and pressure in cerebral
arteries and may relieve the pain of vascular headaches.;