Epoprostenol - CISMeF

Preferred Label : Epoprostenol;

NCIt definition : An oral prostacyclin and a metabolite of arachidonic acid with antihypertensive and platelet inhibitory properties. Epoprostenol binds to prostacyclin receptors on platelet surfaces, subsequently activating platelet membrane adenyl cyclase and resulting in increased cAMP levels. The elevated cAMP triggers signal transduction that leads to vasodilations. In addition, this agent also functions as an antagonist of thromboxane A2, thereby resulting in direct vasodilation of pulmonary and systemic arterial vascular beds, and inhibition of platelet aggregation.;

UNII : DCR9Z582X0;

InChIKey : KAQKFAOMNZTLHT-OZUDYXHBSA-N;

CAS number : 35121-78-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 35121-78-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C20H32O5;

ChEBI ID : CHEBI:15552;

Details

Origin ID

C61748;

UMLS CUI

C0033567;

Currated CISMeF NLP mapping
- Epoprostenol [ICD-11 Extension code]
- Epoprostenol [ICHI extension code]
- Epoprostenol (substance) [SNOMED CT concept]
- Product containing epoprostenol (medicinal product) [SNOMED CT concept]
- epoprostenol [MeSH Descriptor]
- epoprostenol [MeSH concept]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Epoprostenol [ICD-11 Extension code]
- Epoprostenol (substance) [SNOMED CT concept]
- Product containing epoprostenol (medicinal product) [SNOMED CT concept]
- epoprostenol [ATC Code]
- epoprostenol [MeSH concept]
- epoprostenol [MeSH Descriptor]
- prostaglandin pgi2 [SNOMED Notion]
- prostaglandin x [SNOMED Notion]
Validated automatic mappings to BTNT
- epoprostenol [ATC Code]
Validated automatic mappings to NTBT
- prostaglandins I [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Epoprostenol Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Epoprostenol Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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