" /> Entacapone - CISMeF





Preferred Label : Entacapone;

NCIt definition : A nitrocatechol compound with anti-parkinsonian property. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), which catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including dihydroxyphenylalanine (DOPA), catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents the metabolism and inactivation of adjunct drugs, thereby increasing the bioavailability of these compounds by facilitating their passage across the blood-brain barrier.;

UNII : 4975G9NM6T;

InChIKey : JRURYQJSLYLRLN-BJMVGYQFSA-N;

CAS number : 130929-57-6;

Drug name : Comtan;

Chemical formula : C14H15N3O5;

ChEBI ID : CHEBI:4798;

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29/07/2025


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