Entacapone - CISMeF

Preferred Label : Entacapone;

NCIt definition : A nitrocatechol compound with anti-parkinsonian property. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), which catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including dihydroxyphenylalanine (DOPA), catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents the metabolism and inactivation of adjunct drugs, thereby increasing the bioavailability of these compounds by facilitating their passage across the blood-brain barrier.;

UNII : 4975G9NM6T;

InChIKey : JRURYQJSLYLRLN-BJMVGYQFSA-N;

CAS number : 130929-57-6;

Drug name : Comtan;

Chemical formula : C14H15N3O5;

ChEBI ID : CHEBI:4798;

Details

Origin ID

C61746;

UMLS CUI

C0165921;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Entacapone [Substance BNPC]
- Entacapone (substance) [SNOMED CT concept]
- Product containing entacapone (medicinal product) [SNOMED CT concept]
- entacapone [ATC Code]
- entacapone [MeSH Supplementary Concept]
- entacapone [MeSH concept]
Validated automatic mappings to BTNT
- entacapone [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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