Doxylamine - CISMeF

Preferred Label : Doxylamine;

NCIt definition : A first generation ethanolamine with antiinflammatory, sedative and antihistamine properties. Doxylamine competitively inhibits the histamine 1 (H1) receptor, thereby preventing the action of endogenous histamine as well as the subsequent release of pro-inflammatory mediators from basophils and mast cells. This agent acts as an inverse agonist that combines with, and stabilizes the inactive form of the H1-receptor, shifting the H1 receptor equilibrium toward the inactive state. This results in downregulation of nuclear factor-kappaB (NF-kappaB) and NF-kappaB dependent antigen presentation, chemotaxis, as well as expression of cell-adhesion molecules and pro-inflammatory cytokines.;

UNII : 95QB77JKPL;

InChIKey : HCFDWZZGGLSKEP-UHFFFAOYSA-N;

CAS number : 469-21-6;

Chemical formula : C17H22N2O;

ChEBI ID : CHEBI:51380;

Details

Origin ID

C61738;

UMLS CUI

C0013092;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Doxylamine [ICD-11 Extension code]
- Doxylamine [LOINC component]
- Doxylamine (substance) [SNOMED CT concept]
- Product containing doxylamine (medicinal product) [SNOMED CT concept]
- doxylamine [ATC Code]
- doxylamine [Substance BNPC]
- doxylamine [MeSH concept]
- doxylamine [SNOMED Notion]
- doxylamine [MeSH Descriptor]
Validated automatic mappings to BTNT
- doxylamine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Doxylamine Succinate [NCIt concept]
is_free_acid_or_base_form_of
- Doxylamine Succinate [NCIt concept]

Keyword's position in hierarchy(ies) :

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