Doxazosin - CISMeF

Preferred Label : Doxazosin;

NCIt definition : A quinazoline with antihypertensive and antineoplastic properties. Doxazosin is an alpha-adrenergic antagonist that selectively inhibits alpha-1 adrenergic receptors. Blockages of the alpha-1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity. This agent also shows high affinity to alpha-1c adrenoceptor, the predominant functional type in the prostate, which may partially attribute to its effect in treatment of benign prostatic hyperplasia. Furthermore, doxazosin induces apoptosis in prostate cancer cells mediated through inhibition of protein kinase B (PKB)/Akt-signaling death receptor regulatory pathway.;

UNII : NW1291F1W8;

InChIKey : RUZYUOTYCVRMRZ-UHFFFAOYSA-N;

CAS number : 74191-85-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 74191-85-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C23H25N5O5;

ChEBI ID : CHEBI:4708;

Codes from synonyms : 31754;

Details

Origin ID

C61737;

UMLS CUI

C0114873;

Automatic exact mappings (from CISMeF team)
- Doxazosin [ICHI extension code]
See also inter- (CISMeF)
- Product containing doxazosin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Doxazosin [ICD-11 Extension code]
- Doxazosin [LOINC component]
- Doxazosin (substance) [SNOMED CT concept]
- Product containing doxazosin (medicinal product) [SNOMED CT concept]
- doxazosin [ATC Code]
- doxazosin [Substance BNPC]
- doxazosin [MeSH concept]
- doxazosin [MeSH Descriptor]
Validated automatic mappings to BTNT
- doxazosin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Doxazosin Mesylate [NCIt concept]
is_free_acid_or_base_form_of
- Doxazosin Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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