Desonide - CISMeF

Preferred Label : Desonide;

NCIt definition : A synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.;

UNII : J280872D1O;

InChIKey : WBGKWQHBNHJJPZ-LECWWXJVSA-N;

CAS number : 638-94-8;

Drug name : Verdeso; Desonate;

Chemical formula : C24H32O6;

ChEBI ID : CHEBI:204734;

Details

Origin ID

C61702;

UMLS CUI

C0011705;

See also inter- (CISMeF)
- Product containing desonide (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Desonide [ICD-11 Extension code]
- Desonide (substance) [SNOMED CT concept]
- Product containing desonide (medicinal product) [SNOMED CT concept]
- desonide [ATC Code]
- desonide [ATC Code]
- desonide [Substance BNPC]
- desonide [MeSH concept]
- desonide [MeSH Descriptor]
- desonide [SNOMED Notion]
Validated automatic mappings to BTNT
- desonide [ATC Code]
- desonide [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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