" /> Desonide - CISMeF





Preferred Label : Desonide;

NCIt definition : A synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.;

UNII : J280872D1O;

InChIKey : WBGKWQHBNHJJPZ-LECWWXJVSA-N;

CAS number : 638-94-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 638-94-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Verdeso; Desonate;

Chemical formula : C24H32O6;

ChEBI ID : CHEBI:204734;

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09/05/2024


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