NCIt definition : A synthetic octapeptide, and an analogue of human hormone arginine vasopressin with
antidiuretic and coagulant activities. Desmopressin binds to V2 receptors in renal
collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue
plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption.
This agent also increases nitric oxide (NO) production via activation of endothelial
NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin
stimulates the release of factor VIII from endothelial cells mediated through V1a
receptor, thereby promotes blood coagulation.;