Preferred Label : Cyclophosphamide Anhydrous;
NCIt synonyms : 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide; N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide;
NCIt definition : The anhydrous form of cyclophosphamide, a synthetic nitrogen mustard alkylating agent,
with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide
is converted to active metabolites including phosphoramide mustard, which binds to
and crosslinks DNA and RNA, thereby inhibiting DNA replication and protein synthesis.
This agent, at low doses, is also a potent immunosuppressant primarily by depleting
T-regulatory cells.;
UNII : 6UXW23996M;
InChIKey : CMSMOCZEIVJLDB-UHFFFAOYSA-N;
CAS number : 50-18-0;
Chemical formula : C7H15Cl2N2O2P;
ChEBI ID : CHEBI:4027;
Origin ID : C61694;
UMLS CUI : C1880207;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
