Clodronic Acid

Preferred Label : Clodronic Acid;

NCIt synonyms : Clodronate; (Dichloromethylene)bisphosphonic Acid;

NCIt definition : A first-generation bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Clodronic acid adsorbs onto the surface of the hydroxyapatite crystals in bone matrix. Although the exact mechanism through which clodronic acid exerts its cytotoxic effect on osteoclasts has yet to be fully elucidated, this agent is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p. The ATP analog AppCCl2p competitively inhibits ADP/ATP translocase, thereby interfering with mitochondrial membrane potential and cellular energy metabolism. This may cause osteoclast apoptosis and, eventually, inhibiting osteoclast-mediated bone resorption.;

UNII : 0813BZ6866;

InChIKey : ACSIXWWBWUQEHA-UHFFFAOYSA-N;

CAS number : 10596-23-3;

Chemical formula : CH4Cl2O6P2;

ChEBI ID : CHEBI:110423;

Codes from synonyms : 50682; 110;

Details

Origin ID

C61685;

UMLS CUI

C0012081;

Automatic exact mappings (from CISMeF team)
- clodronate [MeSH concept]
Currated CISMeF NLP mapping
- Clodronic acid [ICD-11 Extension code]
- Clodronic acid [ICHI extension code]
- Clodronic acid [SMS substance]
- Clodronic acid (substance) [SNOMED CT concept]
- clodronic acid [Substance BNPC]
- clodronic acid [MeSH Descriptor]
- clodronic acid [MeSH concept]
- clodronic acid [SNOMED Notion]
See also inter- (CISMeF)
- Clodronic acid (product) [Inactive SNOMED CT concept]
- Product containing clodronic acid (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Clodronic acid [ICD-11 Extension code]
- Clodronic acid (product) [Inactive SNOMED CT concept]
- Clodronic acid (substance) [SNOMED CT concept]
- Product containing clodronic acid (medicinal product) [SNOMED CT concept]
- clodronic acid [ATC Code]
- clodronic acid [Substance BNPC]
- clodronic acid [MeSH concept]
- clodronic acid [SNOMED Notion]
- clodronic acid [MeSH Descriptor]
Validated automatic mappings to BTNT
- Clodronate disodium (product) [Inactive SNOMED CT concept]
- clodronate [MeSH concept]
- clodronate disodium [SNOMED Notion]
- clodronic acid [ATC Code]
Validated automatic mappings to NTBT
- Clodronate (substance) [SNOMED CT concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Clodronate Disodium [NCIt concept]
is_free_acid_or_base_form_of
- Clodronate Disodium [NCIt concept]

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