Clodronate Disodium

Preferred Label : Clodronate Disodium;

NCIt synonyms : Clodronic Acid Disodium Salt; Dichloromethylene Diphosphonate; Clodronate;

NCIt related terms : Bonefos;

NCIt definition : The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.;

Alternative definition : NCI-GLOSS: A drug used as treatment for hypercalcemia (abnormally high levels of calcium in the blood) and for cancer that has spread to the bone (bone metastases). It may decrease pain, the risk of fractures, and the development of new bone metastases.;

UNII : N030400H8J;

InChIKey : XWHPUCFOTRBMGS-UHFFFAOYSA-L;

CAS number : 88416-50-6;

Drug name : Ossiten; Clasteon; Loron; Mebonat; Bonefos; Difosfonal;

Molecule name : CL2MDP;

Chemical formula : CH2Cl2O6P2.2Na.4H2O;

NSC code : 713466;

ChEBI ID : CHEBI:59587;

Codes from synonyms : NSC0713466; CDR0000045405;

Details

Origin ID

C1418;

UMLS CUI

C0008994;

Automatic exact mappings (from CISMeF team)
- Clodronate (substance) [SNOMED CT concept]
- clodronate [MeSH concept]
Currated CISMeF NLP mapping
- Clodronate Disodium [MeSH concept]
- Clodronate disodium [SMS substance]
- Clodronate disodium (substance) [SNOMED CT concept]
- clodronate disodium [SNOMED Notion]
See also inter- (CISMeF)
- Clodronate disodium (product) [Inactive SNOMED CT concept]
- Clodronic acid (substance) [SNOMED CT concept]
- clodronic acid [Substance BNPC]
- clodronic acid [MeSH concept]
- clodronic acid [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Clodronate (substance) [SNOMED CT concept]
- Clodronic acid [SMS substance]
- clodronate [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Clodronic Acid [NCIt concept]
is_component_of_chemotherapy_regimen
- Clodronate/Mitoxantrone/Prednisone [NCIt concept]
is_salt_form_of
- Clodronic Acid [NCIt concept]

Keyword's position in hierarchy(ies) :

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