NCIt definition : A synthetic quinazoline compound with smooth muscle relaxing activity. Alfuzosin selectively
binds to and antagonizes alpha-1-adrenergic receptors in smooth muscle of the bladder
neck and prostate, thereby relaxing the smooth muscle and decreasing the obstruction
and urethral resistance seen with benign prostate hyperplasia (BPH) and prostate cancer.
This agent also blocks alpha-1-adrenergic receptors in peripheral vascular smooth
muscle, which leads to vasodilatation and a subsequent decrease in peripheral vascular
resistance.;