Preferred Label : Alendronic Acid;

NCIt synonyms : Alendronate; (4-Amino-1-hydroxybutylidene)bisphosphonic Acid;

NCIt definition : A second generation bisphosphonate and synthetic analog of pyrophosphate with anti-bone-resorption activity. Alendronic acid binds to and inhibits the activity of farnesyl pyrophosphate synthetase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. As a result, bone resorption and turnover are reduced.;

UNII : X1J18R4W8P;

InChIKey : OGSPWJRAVKPPFI-UHFFFAOYSA-N;

CAS number : 66376-36-1;

Chemical formula : C4H13NO7P2;

ChEBI ID : CHEBI:2567;

Codes from synonyms : 50679; 18;

Détails


Position du mot-clé dans l'(les) arborescence(s) : arborescence

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https://www.has-sante.fr/jcms/p_3080485/fr/bonasol
2019
false
false
false
France
Alendronic Acid
osteoporosis, postmenopausal
osteoporotic fractures
hip fractures
spinal fractures
insurance, health, reimbursement
treatment outcome
alendronic acid
administration, oral
bone density conservation agents
alendronate
evaluation of the transparency committee

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28/07/2025


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