Meclizine - CISMeF

Preferred Label : Meclizine;

NCIt synonyms : Meclozine; 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;

NCIt definition : A synthetic piperazine with anti-emetic, sedative and histamine H1antagonistic properties. Meclizine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone.;

UNII : 3L5TQ84570;

InChIKey : OCJYIGYOJCODJL-UHFFFAOYSA-N;

CAS number : 569-65-3;

Chemical formula : C25H27ClN2;

Details

Origin ID

C61610;

UMLS CUI

C0025039;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Meclizine [LOINC component]
- Meclozine (substance) [SNOMED CT concept]
- Product containing meclozine (medicinal product) [SNOMED CT concept]
- meclizine [Substance BNPC]
- meclizine [SNOMED Notion]
- meclizine [MeSH concept]
- meclizine [MeSH Descriptor]
- meclozine [ATC Code]
Validated automatic mappings to BTNT
- meclozine [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Meclizine Hydrochloride [NCIt concept]
- Meclozine Dihydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Meclizine Hydrochloride [NCIt concept]
- Meclozine Dihydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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