Meclizine Hydrochloride

Preferred Label : Meclizine Hydrochloride;

NCIt synonyms : Meclizine HCl; 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine Dihydrochloride Monohydrate; Meclizine Dihydrochloride Monohydrate;

NCIt definition : The hydrochloride salt form of meclizine, a synthetic piperazine with anti-emetic, sedative and histamine H1 antagonistic properties. Meclizine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone.;

UNII : HDP7W44CIO;

InChIKey : KDLHYOMCWBWLMM-UHFFFAOYSA-N;

CAS number : 31884-77-2;

Drug name : Bonine; Antivert;

Chemical formula : C25H27ClN2.2HCl.H2O;

NSC code : 169189;

Codes from synonyms : 31626;

Details

Origin ID

C29245;

UMLS CUI

C0282227;

Automatic exact mappings (from CISMeF team)
- Meclizine (hydrochloride) [ICHI extension code]
- meclizine [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to BTNT
- Meclozine dihydrochloride monohydrate [SMS substance]
Validated automatic mappings to NTBT
- Meclozine [ICD-11 Extension code]
- meclizine [MeSH Descriptor]
- meclizine [Substance BNPC]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Meclizine [NCIt concept]
is_salt_form_of
- Meclizine [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients