Alpha-Lipoic Acid

Preferred Label : Alpha-Lipoic Acid;

NCIt synonyms : Lipoic Acid; 6,8-Thioctic Acid; 5-(1,2-Dithiolan-3-yl)pentanoic Acid; Thioctate;

NCIt related terms : Thioctic Acid; ALPHA LIPOIC ACID;

NCIt definition : A naturally occurring micronutrient, synthesized in small amounts by plants and animals (including humans), with antioxidant and potential chemopreventive activities. Alpha-lipoic acid acts as a free radical scavenger and assists in repairing oxidative damage and regenerates endogenous antioxidants, including vitamins C and E and glutathione. This agent also promotes glutathione synthesis. In addition, alpha-lipoic acid exerts metal chelating capacities and functions as a cofactor in various mitochondrial enzyme complexes involved in the decarboxylation of alpha-keto acids.;

Alternative definition : NCI-GLOSS: A substance that is being studied for its ability to protect normal cells from the side effects of chemotherapy and prevent peripheral neuropathy (numbness, tingling, burning, and weakness in the hands or feet). Alpha-lipoic acid is made by the body and can be found in foods such as organ meats, spinach, broccoli, peas, brussel sprouts, and rice bran. It can also be made in the laboratory. Alpha-lipoic acid is a type of antioxidant and chemoprotective agent.;

UNII : 73Y7P0K73Y;

InChIKey : AGBQKNBQESQNJD-UHFFFAOYSA-N;

CAS number : 1077-28-7;

Chemical formula : C8H14O2S2;

ChEBI ID : CHEBI:16494;

Codes from synonyms : CDR0000443026; 03352;

Details

Origin ID

C61595;

UMLS CUI

C0023791;

Automatic exact mappings (from CISMeF team)
- Thioctic acid [ICHI extension code]
Currated CISMeF NLP mapping
- 5-(1,2-dithiolan-3-yl)valeric acid [Substance BNPC]
- Lipoic acid (substance) [SNOMED CT concept]
- Product containing lipoic acid (medicinal product) [SNOMED CT concept]
- Thioctic acid [ICD-11 Extension code]
- lipoic acid [SNOMED Notion]
- thioctic acid [MeSH Descriptor]
- thioctic acid [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
- Vitamin [UMLS semantic type]
UMLS correspondences (same concept)
- 5-(1,2-dithiolan-3-yl)valeric acid [Substance BNPC]
- Lipoic acid (substance) [SNOMED CT concept]
- Product containing lipoic acid (medicinal product) [SNOMED CT concept]
- Thioctic acid [ICD-11 Extension code]
- lipoic acid [SNOMED Notion]
- thioctic acid [MeSH concept]
- thioctic acid [MeSH Descriptor]
- tioctic acid [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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