Preferred Label : Bendamustine Hydrochloride;
NCIt synonyms : Cytostasan Hydrochloride; Bendamustin Hydrochloride; 2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochloride;
NCIt related terms : Treanda;
NCIt definition : The hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative
with alkylator and antimetabolite activities. Bendamustine possesses three active
moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue;
and a butyric acid side chain. Although its exact mechanism of action is unknown this
agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate
and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition,
and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that
it may be more potent in activating p53-dependent stress pathways and inducing apoptosis;
it may induce mitotic catastrophe; and it may activate a base excision DNA repair
pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent
may be more efficacious and less susceptible to drug resistance than other alkylators.;
Alternative definition : NCI-GLOSS: A drug used to treat chronic lymphocytic leukemia (CLL). It is also used
to treat slow-growing B-cell non-Hodgkin lymphoma (NHL) that has gotten worse within
6 months of treatment with other anticancer drugs.It is being studied in the treatment
of other types of cancer. Bendamustine hydrochloride may damage the DNA in cancer
cells and cause them to die. It is a type of alkylating agent and a type of antimetabolite.;
UNII : 981Y8SX18M;
InChIKey : ZHSKUOZOLHMKEA-UHFFFAOYSA-N;
CAS number : 3543-75-7;
Drug name : Ribomustin; Treanda; Bendeka; Levact; Belrapzo; Treakisym; VIVIMUSTA;
Molecule name : SyB L-0501; CEP-18083; CEP 18083;
Chemical formula : C16H21Cl2N3O2.ClH;
NSC code : 138783;
Codes from synonyms : CDR0000386197; CDR0000594104;
Origin ID : C61565;
UMLS CUI : C0772139;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_component_of_chemotherapy_regimen
- is_salt_form_of
https://pgtmsite.files.wordpress.com/2024/01/guide_traitement_fong_lev_can_ped_20210409_final.pdf
2021
Canada
drug information
During Treatment
GDC Treatment Frequency Terminology
Yeast Cell Measurement
Bendamustine Hydrochloride
No Treatment for Diabetes
candidemia
Fungemia
Treatment Epoch
fungemia
yeasts
Biomaterial Treatment
pediatrician
Therapy Object
On Treatment
Pediatric
Treatment
yeast, nos
Treat
Splayed
Fungemia, CTCAE
Pediatric
Yeast
Yeast Present
Review
Treatment Study
pediatrics
candidemia
Epithelial Cell Aggregation and Separation
systemic mycosis, nos
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