NCIt definition : A liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase
(GST) P1-1 with hematopoiesis-stimulating activity. After intracellular de-esterification,
the active form of TLK199 (TLK117) binds to and inhibits GST P1-1, thereby restoring
Jun kinase and MAPK pathway activities and promoting MAPK-mediated cellular proliferation
and differentiation pathways. This agent promotes the proliferation and maturation
of hematopoietic precursor cells, granulocytes, monocytes, erythrocytes and platelets.;
UNII : D59N834676;
InChIKey : XJDYQYNYISTAMO-GFDYFVENSA-N;
CAS number : 286942-97-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 286942-97-0
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