Ezatiostat Hydrochloride

Preferred Label : Ezatiostat Hydrochloride;

NCIt definition : A liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity. After intracellular de-esterification, the active form of TLK199 (TLK117) binds to and inhibits GST P1-1, thereby restoring Jun kinase and MAPK pathway activities and promoting MAPK-mediated cellular proliferation and differentiation pathways. This agent promotes the proliferation and maturation of hematopoietic precursor cells, granulocytes, monocytes, erythrocytes and platelets.;

UNII : D59N834676;

InChIKey : XJDYQYNYISTAMO-GFDYFVENSA-N;

CAS number : 286942-97-0;

Drug name : Telintra;

Molecule name : TLK199; TER199;

Chemical formula : C27H35N3O6S.HCl;

Details

Origin ID

C61326;

UMLS CUI

C2700601;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Ezatiostat [NCIt concept]
has_target
- Glutathione S-Transferase P [NCIt concept]
is_salt_form_of
- Ezatiostat [NCIt concept]

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