Talimogene Laherparepvec

Preferred Label : Talimogene Laherparepvec;

NCIt synonyms : OncoVEX GM-CSF; GM-CSF-Encoding Oncolytic Herpes Simplex Virus Vaccine; ICP34.5-, ICP47-deleted Herpes Simplex Virus 1 (HSV-1) Incorporating the Human GM-CSF Gene; T-VEC;

NCIt definition : An ICP34.5, ICP47-deleted, oncolytic herpes simplex type-1 virus (HSV-1) based on the JS1 strain, and encoding the immunostimulating factor human cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential immunostimulating and antineoplastic activities. Upon intratumoral injection, talimogene laherparepvec selectively infects and replicates in tumor cells, thereby inducing tumor cell lysis. In addition, GM-CSF attracts dendritic cells (DCs) and may stimulate a cytotoxic T cell response against tumor cells, which results in immune-mediated tumor cell death. Deletion of the gene encoding for ICP34.5 provides tumor selectivity and prevents replication in healthy cells. As ICP47 blocks antigen presentation in HSV-infected cells, deletion of this gene may induce a more potent antitumor immune response in the tumor cells. Additionally, deletion of ICP47 causes increased expression of the HSV US11 gene and allows US11 to be expressed as an immediate early and not a late gene. This further enhances the degree of viral replication and oncolysis of tumor cells.;

UNII : 07730V90L6;

CAS number : 1187560-31-1;

Drug name : Imlygic;

Molecule name : JS1 34.5-hGMCSF 47- pA-;

Codes from synonyms : 477;

Details

Origin ID

C61314;

UMLS CUI

C1831828;

CISMeF manual mappings
- Talimogene laherparepvec (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing talimogene laherparepvec (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Virus [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing talimogene laherparepvec (medicinal product) [SNOMED CT concept]
- Talimogene laherparepvec (substance) [SNOMED CT concept]
- talimogene laherparepvec [ATC Code]
- talimogene laherparepvec [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- talimogene laherparepvec [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Talimogene Laherparepvec Intralesional Regimen [NCIt concept]
- Talimogene Laherparepvec Regimen [NCIt concept]

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Main resources

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