Preferred Label : Noscapine Hydrochloride;
NCIt synonyms : Narcotine hydrochloride; Noscapine HCl; 1(3H)Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3,-dioxolo(4,5-g)isoquinolin-5-yl)-hydrochloride;
NCIt definition : The orally available hydrochloride salt of the opioid agonist noscapine, a phthalideisoquinoline
alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive,
and potential antineoplastic activities. Noscapine binds to tubulin and alters its
conformation, resulting in a disruption of the dynamics of microtubule assembly (by
increasing the time that microtubules spend idle in a paused state) and subsequently,
the inhibition of mitosis and tumor cell death. Unlike other tubulin inhibitors such
as the taxanes and vinca alkaloids, noscapine does not affect microtubule polymerization.;
UNII : TTN62ITH9I;
InChIKey : MFLVZFXCSKVCSH-URBRKQAFSA-N;
CAS number : 912-60-7;
Chemical formula : C22H23NO7.HCl;
Origin ID : C61103;
UMLS CUI : C1450474;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
