Noscapine Hydrochloride

Preferred Label : Noscapine Hydrochloride;

NCIt synonyms : Narcotine hydrochloride; Noscapine HCl; 1(3H)Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3,-dioxolo(4,5-g)isoquinolin-5-yl)-hydrochloride;

NCIt definition : The orally available hydrochloride salt of the opioid agonist noscapine, a phthalideisoquinoline alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine binds to tubulin and alters its conformation, resulting in a disruption of the dynamics of microtubule assembly (by increasing the time that microtubules spend idle in a paused state) and subsequently, the inhibition of mitosis and tumor cell death. Unlike other tubulin inhibitors such as the taxanes and vinca alkaloids, noscapine does not affect microtubule polymerization.;

UNII : TTN62ITH9I;

InChIKey : MFLVZFXCSKVCSH-URBRKQAFSA-N;

CAS number : 912-60-7;

Chemical formula : C22H23NO7.HCl;

Details

Origin ID

C61103;

UMLS CUI

C1450474;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Noscapine [NCIt concept]
has_target
- Tubulin [NCIt concept]
is_salt_form_of
- Noscapine [NCIt concept]

Keyword's position in hierarchy(ies) :

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