Levodopa - CISMeF

Preferred Label : Levodopa;

NCIt synonyms : (--)-3-(3,4-Dihydroxyphenyl)-L-alanine; beta-(3,4-Dihydroxyphenyl)-L-alanine; (--)-2Amino-3-(3,4-dihydroxyphenyl)propanoic Acid;

NCIt related terms : 3-Hydroxy-L-tyrosine; Dopasol; Eldopar; (-)-3-(3,4-Dihydroxyphenyl)-L-alanine; L-DOPA; 3-(3,4-Dihydroxyphenyl)-L-alanine; Bendopa; Dopalina; Dopar; Levopa; Deadopa; Cidandopa; L(-)-Dopa; Dopaidan; Larodopa; Maipedopa; Eldopal; .beta.-(3,4-Dihydroxyphenyl)-L-alanine; L-.beta.-(3,4-Dihydroxyphenyl)alanine;

NCIt definition : An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS.;

UNII : 46627O600J;

InChIKey : WTDRDQBEARUVNC-LURJTMIESA-N;

CAS number : 59-92-7;

Drug name : Dopaflex; Levopa; Eldopal; Maipedopa; Ledopa; Eurodopa; Laradopa; Eldopar; Dopalina; Dopal; Bendopa; Eldopatec; Cidandopa; Deadopa; Dopasol; Dopar; Doparkine; Doparl; Veldopa; Dopaston; Parda; Dopastral; Larodopa; Dopaidan; Doprin;

Chemical formula : C9H11NO4;

NSC code : 118381;

ChEBI ID : CHEBI:15765;

Codes from synonyms : NSC0118381;

Details

Origin ID

C611;

UMLS CUI

C0023570;

Automatic exact mappings (from CISMeF team)
- Dihydroxyphenylalanine (substance) [SNOMED CT concept]
- dihydroxyphenylalanine [MeSH Descriptor]
Currated CISMeF NLP mapping
- L-dopa [LOINC component]
- Levodopa [Substance BNPC]
- Levodopa [Vue CIM-11]
- Levodopa [SMS substance]
- Levodopa [LOINC component]
- levodopa [MeSH Descriptor]
- levodopa [MeSH concept]
- levodopa [SNOMED Notion]
See also inter- (CISMeF)
- Product containing levodopa (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- L-dopa [LOINC component]
- Levodopa [Substance BNPC]
- Levodopa [Vue CIM-11]
- Levodopa [LOINC component]
- Product containing levodopa (medicinal product) [SNOMED CT concept]
- levodopa [ATC Code]
- levodopa [SNOMED Notion]
- levodopa [MeSH concept]
- levodopa [MeSH Descriptor]
Validated automatic mappings to BTNT
- levodopa [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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