" /> Tinzaparin Sodium - CISMeF





Preferred Label : Tinzaparin Sodium;

NCIt synonyms : Tinzaparin Sodium Injection; Tinzaparin; Enzyme Depolymerized Heparin (MW 6500);

NCIt related terms : Innohep;

NCIt definition : The sodium salt of a low molecular weight heparin (LMWH), obtained by controlled enzymatic depolymerization of heparin from porcine intestinal mucosa, with antithrombotic properties. Tinzaparin is a potent inhibitor of several activated coagulation factors, especially Factors Xa and IIa (thrombin); its primary activity is mediated through the plasma protease inhibitor antithrombin. In addition, this agent may inhibit angiogenesis through: 1) competitive binding of the heparin-binding sites on endothelial cells for the proangiogenic cytokines vascular endothelial growth factor (VEGF) and beta-fibroblast growth factor (beta-FGF) and 2) increasing the release of tissue factor pathway inhibitor (TFPI), a negative regulator of angiogenesis.;

Alternative definition : NCI-GLOSS: A drug that is used with another drug, warfarin, to treat blood clots that form deep in the veins and to prevent new blood clots from forming. It is a type of anticoagulant.;

UNII : 3S182ET3UA;

CAS number : 9041-08-1;

Drug name : Logiparin; Inno-hep;

Molecule name : LNH-1;

Chemical formula : (C14H18NO11)n.2(C12H15NO13S)n.3Na.3O3S;

Codes from synonyms : CDR0000513077; CDR0000513078;

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04/05/2025


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