Ketoconazole - CISMeF

Preferred Label : Ketoconazole;

NCIt synonyms : Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine;

NCIt definition : A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04);

Alternative definition : NCI-GLOSS: A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.;

UNII : R9400W927I;

InChIKey : XMAYWYJOQHXEEK-ZEQKJWHPSA-N;

CAS number : 65277-42-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 65277-42-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Orifungal M; Fungoral; Ketoderm; Fungarest; Nizoral; Xolegel; Panfungol; Ketoisdin;

Molecule name : R-41400;

Chemical formula : C26H28Cl2N4O4;

NSC code : 317629;

ChEBI ID : CHEBI:47519;

Codes from synonyms : CDR0000045222; NSC0317629; 20436; 290;

Details

Origin ID

C605;

UMLS CUI

C0022625;

Automatic exact mappings (from CISMeF team)
- ketoconazole [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ketoconazole [ICD-11 Extension code]
- Ketoconazole [LOINC component]
- Ketoconazole (substance) [SNOMED CT concept]
- Product containing ketoconazole (medicinal product) [SNOMED CT concept]
- ketoconazole [ATC Code]
- ketoconazole [ATC Code]
- ketoconazole [ATC Code]
- ketoconazole [Substance BNPC]
- ketoconazole [ATC Code]
- ketoconazole [SNOMED Notion]
- ketoconazole [MeSH concept]
- ketoconazole [MeSH Descriptor]
Validated automatic mappings to BTNT
- ketoconazole [ATC Code]
- ketoconazole [ATC Code]
- ketoconazole [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- Operational Ontology for Radiation Oncology Prostate Cancer Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Alendronate Sodium/Ketoconazole [NCIt concept]
- Carboxyamidotriazole/Ketoconazole [NCIt concept]
- Cyclosporine/Dipyridamole/Etoposide/Ketoconazole/Metronidazole/Quinidine/Tamoxifen [NCIt concept]
- Dipyridamole/Etoposide/Ketoconazole/Metronidazole [NCIt concept]
- Dipyridamole/Etoposide/Ketoconazole/Metronidazole/Quinidine/Tamoxifen [NCIt concept]
- Dipyridamole/Etoposide/Ketoconazole/Metronidazole/Tamoxifen [NCIt concept]
- Docetaxel/Ketoconazole [NCIt concept]
- Doxorubicin/Ketoconazole [NCIt concept]
- Etoposide/Ketoconazole/Metronidazole [NCIt concept]
- Flutamide/Ketoconazole [NCIt concept]
- Flutamide/Ketoconazole/Leuprolide [NCIt concept]
- Hydrocortisone/Ketoconazole [NCIt concept]
- Hydrocortisone/Ketoconazole Regimen [NCIt concept]
- KAVE Regimen [NCIt concept]
- Ketoconazole/Paclitaxel [NCIt concept]
- Ketoconazole/Tretinoin [NCIt concept]

Keyword's position in hierarchy(ies) :

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