" /> Ketoconazole - CISMeF





Preferred Label : Ketoconazole;

NCIt synonyms : Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine;

NCIt definition : A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04);

Alternative definition : NCI-GLOSS: A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.;

UNII : R9400W927I;

InChIKey : XMAYWYJOQHXEEK-ZEQKJWHPSA-N;

CAS number : 65277-42-1;

Drug name : Orifungal M; Fungoral; Ketoderm; Fungarest; Nizoral; Xolegel; Panfungol; Ketoisdin;

Molecule name : R-41400;

Chemical formula : C26H28Cl2N4O4;

NSC code : 317629;

ChEBI ID : CHEBI:47519;

Codes from synonyms : CDR0000045222; NSC0317629; 20436; 290;

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02/07/2025


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