Recombinant Interleukin-1-beta

Preferred Label : Recombinant Interleukin-1-beta;

NCIt synonyms : interleukin-1-beta; IL-1-b;

NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine interleukin 1 (IL-1)-beta. Produced by monocytes and activated macrophages, endogenous mature IL-1 is generated through proteolytic cleavage by proteases such as IL-1-beta converting enzyme (ICE). This agent promotes angiogenesis, fibroblast proliferation, and neutrophil chemotaxis; it also regulates the functions of lymphocytes and epithelial cells and is involved in the 'acute phase response' to infection. (NCI04);

Details

Origin ID

C585;

UMLS CUI

C1522432;

See also inter- (CISMeF)
- Interleukin 1 beta [LOINC component]
- Interleukin 1-beta [OMIM gene]
- Interleukin-1 beta (substance) [SNOMED CT concept]
- Interleukin-1beta [MeSH concept]
- Interleukin-1beta [MeSH Descriptor]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Cyclophosphamide/Interleukin-1-Beta [NCIt concept]
- Carboplatin/Etoposide/Interleukin-1-Beta [NCIt concept]
- Filgrastim/Interleukin-1-Beta [NCIt concept]
- Fluorouracil/Interleukin-1-Beta [NCIt concept]
- Interferon Gamma/Interleukin-1-Beta/Interleukin-2/Sargramostim/Tumor Necrosis Factor [NCIt concept]
- Interleukin-1-Beta/Interleukin-2 [NCIt concept]
is_related_to_endogenous_product
- Interleukin-1 Beta [NCIt concept]

Keyword's position in hierarchy(ies) :

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