Pibenzimol - CISMeF

Preferred Label : Pibenzimol;

NCIt synonyms : Pibenzimol Hydrochloride; Phenol, p-[5-[5-(4-methyl-1-piperazinyl)-2-benzimidazolyl]-2- benzimidazolyl]-, Trihydrochloride; Bisbenzimidazole; Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, Trihydrochloride;

NCIt related terms : Hoechst dye 33258; Hoe 33258;

NCIt definition : A fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase I, and DNA polymerase, thereby preventing DNA replication. This agent prolongs the G2 phase of the cell cycle and initiates apoptosis in tumor cells. (NCI04);

UNII : LHQ7J5KV9B;

InChIKey : INAAIJLSXJJHOZ-UHFFFAOYSA-N;

CAS number : 23491-45-4;

Molecule name : HOE 33258; Hoechst 33258;

Chemical formula : C25H24N6O;

NSC code : 322921;

ChEBI ID : CHEBI:52082;

Codes from synonyms : NSC0322921;

Details

Origin ID

C546;

UMLS CUI

C0019832;

Automatic exact mappings (from CISMeF team)
- bis-benzimidazole [MeSH concept]
- bis-benzimidazole [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- bisbenzimidazole [MeSH Descriptor]
- bisbenzimidazole [MeSH concept]
- p-(5-(5-(4-methylpiperazin-1-yl)benzimidazol-2-yl)benzimidazol-2-yl)phenol [Substance BNPC]
Semantic type(s)
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- bisbenzimidazole [MeSH concept]
- bisbenzimidazole [MeSH Descriptor]
- p-(5-(5-(4-methylpiperazin-1-yl)benzimidazol-2-yl)benzimidazol-2-yl)phenol [Substance BNPC]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients