Preferred Label : DLEU1 wt Allele;
NCIt synonyms : BCMS; B-Cell Neoplasia-Associated Gene with Multiple Splicing; LEU1; Leukemia Associated Gene 1; NCRNA00021; DLEU1; Deleted in Lymphocytic Leukemia 1; Long Intergenic Non-Protein Coding RNA 21 Gene; DLB1; LINC00021; Deleted in Lymphocytic Leukemia 1 (Non-Protein Coding) wt Allele; Deleted in Lymphocytic Leukemia, 1 Gene; Non-Protein Coding RNA 21 Gene; BCMS1;
NCIt definition : Human DLEU1 wild-type allele is located in the vicinity of 13q14.3 and is approximately
23 kb in length. This allele, which encodes leukemia-associated protein 1, is involved
in tumor suppression. Frequently, the allele has been found to be deleted in chronic
lymphocytic leukemia.;
NCIt note : DLEU1 lacks a TATA box, appears to have many cis-acting elements, and encodes a putative
tumor suppressor DLEU1 Protein for BCLL. Expression of a 1.1-kb transcript occurs
in testis, thymus, small intestine, prostate, spleen, peripheral blood lymphocytes,
and ovary. Approximately 300-bp apart, DLEU1 and DLEU2 are arranged head-to-head and
transcribed in opposite directions. LEU1 is a small portion of the BCMS gene, spanning
at least 560-kb and composed of 50 exons or more expressed in more than 20 tissue-specific
RNA splice variants. BCMS transcripts may be noncoding RNAs.; For the DLEU1 gene, HGNC states the Locus Type as RNA, long non-coding and EntrezGene
indicates the Gene type is ncRNA but UniProt indicates that there is Experimental
evidence at protein level.;
GenBank Accession Number : NR_002605;
Origin ID : C54434;
UMLS CUI : C1705557;
OMIM relation
- Semantic type(s)
- gene_associated_with_disease
- gene_found_in_organism
- gene_has_physical_location
- gene_in_chromosomal_location
- gene_plays_role_in_process
